您的位置: 首页 > 农业专利 > 详情页

IDO AND TDO INHIBITOR COMPOUNDS
专利权人:
IOMET PHARMA LTD;АЙОМЕТ ФАРМА ЛТД
发明人:
Phillip,Филлип,Alan,Алан,Susan,Сьюзан,Michael,Майкл
申请号:
EA201692010
公开号:
EA032760B1
申请日:
2015.03.19
申请国别(地区):
EA
年份:
2019
代理人:
摘要:
The invention relates to a compound of formulaor a pharmaceutically acceptable salt thereof, wherein each R1, R2, R3 and R4 is independently selected from H, halogen, -CN, C1-C6 alkyl, halogenated C1-C6 alkyl, -OH, C1-C7 alkoxy, -OCF3, -C(O)-NH2, -C(O)-NHMe, -NH-SO2Me, -NH-SO2Et, -NH-SO2Pr and -NH-SO2iPr; R5 is H; R7 and R61 are selected from H and C1-C6 alkyl; and R65 is a a heterocyclic group selected from pyrazole-1-yl, pyrazole-3-yl, pyrazole-4-yl, pyrazole-5-yl, 1,2,3-triazole-1-yl, 1,2,3-triazole-4-yl, 1,2,3-triazole-5-yl, 1,2,4-triazole-1-yl, 1,2,4-triazole-3-yl, 1,2,4-triazole-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-6-yl, piperidine-1-yl, piperidine-2-yl, piperidine-3-yl, piperidine-4-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, tetrazole-1-yl, tetrazole-2-yl and tetrazole-5-yl; each of which is optionally substituted with one to three substituents independently selected from halogen, methyl, ethyl, propyl, C(O)-methyl, -S(O)2-methyl and phenyl; and R63 and R64 together form a 3-6 membered carbocyclic or heterocyclic ring selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, oxetanyl, tetrahydrofuranyl and tetrahydropyranyl. The invention also relates to a pharmaceutical composition capable of inhibiting indoleamine-2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) activity and comprising said compound or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable additive or excipient.Изобретение относится к соединению формулыили его фармацевтически приемлемой соли, в которой каждый из R1, R2, R3 и R4 независимо выбран из H, галогена, -CN, C1-C6 алкила, галогенированного C1-C6 алкила, -OH, C1-C7 алкокси, -OCF3, -C(O)-NH2, -C(O)-NHMe, -NH-SO2Me, -NH-SO2Et, -NH-SO2Pr и -NH-SO2iPr; R5 представляет собой H; R7 и R6
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充