Smith, Eric,Fandl, James P.,Rafique, Ashique,Stevens, Sean,Fairhurst, Jeanette L.,Papadopoulos, Nicholas J.,Karow, Margaret,Huang, Tammy T.,Martin, Joel H.,Pobursky, Kevin J.,Chen, Gang
申请号：
AU2007254831
公开号：
AU2007254831B2
申请日:
2007.06.01
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a K of about 500 pM or less and blocks IL-6 activity with an IC of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.
