STEVENS, SEAN,HUANG, TAMMY T.,MARTIN, JOEL H.,FAIRHURST, JEANETTE L.,RAFIQUE, ASHIQUE,SMITH, ERIC,POBURSKY, KEVIN J.,PAPADOPOULOS, NICHOLAS J.,FANDL, JAMES P.,CHEN, GANG,KAROW, MARGARET
申请号：
CA2652976
公开号：
CA2652976C
申请日:
2007.06.01
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.
