Microorganism for drug delivery for the treatment of gastrointestinal diseases expressing and secreting P8 protein and pharmaceutical composition containing the same for prevention or treatment of gastrointestinal diseases
The present invention relates to a drug delivery microorganism capable of being transformed by a gene construct containing a therapeutically active peptide, being safely transmitted into the intestine by oral administration, and expressing and secreting the therapeutic peptide in the gastrointestinal tract, and a gastrointestinal tract disease containing the same. The present invention relates to a pharmaceutical composition for prevention or treatment, and the present invention is to develop a lactic acid bacterium drug delivery system that introduces a lactic acid bacterium-derived anticancer protein into a lactic acid bacterium expression and secretion system and overexpresses and secretes it. It is expected to be widely used in the medical field as a therapeutic agent for natural protein colorectal disease.本発明は治療活性ペプチドを含む遺伝子コンストラクトによって形質転換され、経口投与によって腸内に安全に伝達されて治療ペプチドを胃腸管で発現及び分泌することができる薬物伝達用微生物及びそれを含む胃腸管疾患予防又は治療用薬剤学的組成物に関するものであり、本発明は乳酸菌来由坑癌タンパク質を乳酸菌発現及び分泌システムに導入し、これを過発現及び分泌する乳酸菌薬物伝達システムを開発したものであり、天然タンパク質大腸疾患治療剤として医学分野に大きく活用されることに期待される。
