High efficiency gene transfer and expression in mammalian cells by multiple transfection procedures of MAR sequences

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专利权人:

セレキス エスアー

发明人:

メルモ、ニコラ,ジロ、ピエール アラン,ブシェール、フィリップ,ヌエン、デュク－クァング,カラブレセ、ダヴィ,ソジュ、ダミアン,プティーニ、ステファニア,ヌエン、デュク-クァング

申请号：

JP2006536060

公开号：

JP5396653B2

申请日:

2004.10.22

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to purified and isolated DNA sequences having protein production increasing activity and more specifically to the use of matrix attachment regions (MARs) for increasing protein production activity in a eukaryotic cell. Also disclosed is a method for the identification of said active regions, in particular MAR nucleotide sequences, and the use of these characterized active MAR sequences in a new multiple transfection method.

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