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SYSTEMES ET PROCEDES DE FABRICATION DE LIPOSOMES
专利权人:
Protiva Biotherapeutics Inc.
发明人:
申请号:
EP06761194.7
公开号:
EP1937213B1
申请日:
2006.07.27
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.
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