Ian MacLachlan;Kieu Lam;Lloyd B. Jeffs;Edward Yaworski
发明人:
Ian MacLachlan,Lloyd B. Jeffs,Edward Yaworski,Kieu Lam
申请号：
US11495150
公开号：
US09005654B2
申请日:
2006.07.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.
