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Systems and methods for manufacturing liposomes
专利权人:
Inc.;Protiva Biotherapeutics
发明人:
Jeffs, Lloyd B.,MacLachlan, Ian,Yaworski, Edward,Lam, Kieu
申请号:
AU2006274413
公开号:
AU2006274413B2
申请日:
2006.07.27
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. A therapeutic agent, such as a nucleic acid, is included in one of the buffer solution or the lipid solution. Upon mixing a liposome encapsulating the therapeutic product is substantially instantaneously formed. Thereafter the liposome solution formed is immediately diluted with buffer solution to enhance homogeneity and maintain small particle size.
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