PROBLEM TO BE SOLVED: To simply obtain liposolubility drug internal capsule nanoparticles in which storage stability is excellent without using an organic solvent.SOLUTION: The method of manufacturing nanoparticles by preparing a nanoparticle dispersion under the organic solvent absence includes: a process 1 which mixes an aqueous solution of (A) an ingredient which is a 10C-36C fatty acid and/or fatty acid salt, (B) an ingredient which is a surfactant, and (C) which is a liposolubility drug and a process 2 which mixes a liquid obtained in the process 1, (D) an ingredient which is an acid, and/or (E) an ingredient which is a divalent to a trivalent metal salt.COPYRIGHT: (C)2011,JPO&INPIT【課題】保存安定性が優れる脂溶性薬物内包ナノ粒子を、有機溶剤を用いることなく簡便に得る。【解決手段】有機溶剤不存在下でナノ粒子分散液を調製することによりナノ粒子を製造する方法は、炭素数10~36の脂肪酸及び/又は脂肪酸塩である(A)成分の水溶液と界面活性剤である(B)成分及び脂溶性薬物である(C)とを混合する工程1と、前記工程1で得られた液と酸である(D)成分及び/又は2価~3価の金属塩である(E)成分とを混合する工程2と、を含む。【選択図】なし
