PAUL MICHAEL SCOLA,JULIANG ZHU,NINGNING XU,ALAN XIANGDONG WANG,LI SUN,MARK GEORGE QIANG - SAULNIER,KYLE E. PARCELLA,ERIC MULL,ZHAOXING MENG,DAVID R. LANGLEY,PIYASENA HEWAWASAM,KATHERINE A. GRANT-YOUNG
申请号：
ARP160103159
公开号：
AR106378A1
申请日:
2016.10.14
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
1. Claim 1: a compound characterized by formula (1),Or a pharmaceutically acceptable salt, where m is 0, 1 or 2； Z is h-ch-832323 or or1；wherein R¹ is selected from hydrogen, C₃₋₆alkenyl, haloC₁₋₄alkyl, hydroxyC₁₋₄alkyl, - (CH₂) ₙX and - (CH₂) ₙAr； n is 1, 2, 3 or 4； X is selected from hydrogen, -CH₃,-CF8323,C alcoxi -N (CH)Cycloalkyl optionally substituted with one or two halo groups, -CN, -CO₂Rᵍ,-C (O) NH-C (O) N (CH)1. Adoption of the agenda and organization of work.morpholinyl, tetrahydropyranyl, pyrrolidonyl optionally substituted with one hydroxy group and piperidinyl optionally substituted with one or two groups independently selected from C₁₋₄alkyl, carboxy, hydroxy and C₁₋₄alkoxycarbonyl； Rᵍ is selected from hydrogen and C₁₋₄alkyl； and Ar is selected from benzodioxanyl, indazolyl, isoquinolinyl, isoxazolyl, naphthyl, oxadiazolyl, phenyl； pyridinyl, pyrimidinyl, and quinolinyl； wherein each ring is optionally substituted with 1, 2, 3 or 4 substituents independently selected from C₁₋₄alkoxy, C₁₋₄alkoxycarbonyl, C₁₋₄alkoxycarbonylamino, C₁₋₄alkyl, C₁₋₄alkylcarbonyl,(c) Value value of one or more or one or one different value value value, but different value of halo group, phenyl carbides, pyrethroids, Tetrahydropyridine and a formula compound (3),Q is 0, 1, 2, 3 or 4, while t, Z and r7611 are defined as follows； a is selected from - ch83222； or-8-832222-- (CH) --CH=CH---C (O) NH- y -NHC (O) -2. Each group represents the left and right phenyl rings； 2. Select (4) and (5) from the formula compounds；wherein Rᵐ is selected from hydrogen, C₁₋₃alkyl, -C ° C-Ph, halo, haloC₁₋₃alkyl and a residue of formula (6)；R83199e selected from hydrogen, c83218331-83323； tar, halogen, halogenated 833183232b； tar and other formulations (6)；Y is selected from hydrogen, C₁₋₃alkoxy, C₁₋₃alkyl, cyano and halo； R⁵ is selected from hydrogen, C₁₋₃alkyl, cyano, halo, haloC₁₋₃alkyl and the rest of formula (6)；RL is selected from hydrogen, C₁₋₃alkyl, cyano, halo and haloC₁₋₃alkyl； R⁶ and R⁵
