Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders农业专利-农业专业知识服务系统

发明人:: CASTILLO, GERARDO, M.,LAKE, THOMAS, P.,NGUYEN, BETH, P.,SANDERS, VIRGINIA, J.,SNOW, ALAN, D.

摘要：: A composition of matter that includes at least one of the peptide sequences； Arg-Val-Ala-Val-Ile-Met-Gly-amide (DP-068) and Leu-Ala-Phe-Val-Leu-Arg-Lys-amide (DP-074). A pharmaceutical composition that includes peptides Arg-Val-Ala-Val-Ile-Met-Gly-amide (DP-068) and Leu-Ala-Phe-Val-Leu-Arg-Lys-amide (DP-074). Use of the peptides for preparation of a medicament for the treatment of a diseases characterized by A² fibrillogenesis. Use of an antibody directed against a peptide comprising Leu-Ala-Phe-Val-Leu-Arg-Lys-amide in the manufacture of a medicament for the treatment of a disease characterized by A² fibrillogenesis. Preferably where at least one amino acid of the peptide sequence is a D-amino acid.