Peptides de petite taille pour le traitement de la maladie d'Alzheimer et d'autres troubles de fibrillogénèse de la protéine beta-amyloide

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专利权人:

PROTEOTECH INC.

发明人:

申请号：

EP11161614.0

公开号：

EP2380583B1

申请日:

2004.12.17

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

A composition of matter that includes at least one of the peptide sequences； Arg-Val-Ala-Val-Ile-Met-Gly-amide (DP-068) and Leu-Ala-Phe-Val-Leu-Arg-Lys-amide (DP-074). A pharmaceutical composition that includes peptides Arg-Val-Ala-Val-Ile-Met-Gly-amide (DP-068) and Leu-Ala-Phe-Val-Leu-Arg-Lys-amide (DP-074). Use of the peptides for preparation of a medicament for the treatment of a diseases characterized by A² fibrillogenesis. Use of an antibody directed against a peptide comprising Leu-Ala-Phe-Val-Leu-Arg-Lys-amide in the manufacture of a medicament for the treatment of a disease characterized by A² fibrillogenesis. Preferably where at least one amino acid of the peptide sequence is a D-amino acid.

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