SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES

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专利权人:

Warszawski Uniwersytet Medyczny

发明人:

ZAGOZDZON, Radoslaw,FIRCZUK, Malgorzata

申请号：

EP20150461585

公开号：

EP3181118(A1)

申请日:

2015.12.14

申请国别(地区):

欧洲专利局

年份:

2017

代理人:

摘要：

The present invention relates to a prooxidant synergistic combination to treat B-cell malignancies, such as B cell lymphomas, which comprises a thioredoxin reductase inhibitor, selected from a group comprising auranofin and SK053, and L- or D-ascorbate. The combination of the invention exerts synergistic cytotoxic effects towards malignant, but not normal B cells.

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