CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES

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专利权人:

WYETH HOLDINGS CORPORATION

发明人:

KUNZ, ARTHUR,MORAN, JUSTIN, KEITH,RUBINO, JOSEPH, THOMAS,JAIN, NEERA,VIDUNAS, EUGENE, JOSEPH,SIMPSON, JOHN, MCLEAN,ROBBINS, PAUL, DAVID,MERCHANT, NISHITH,DIJOSEPH, JOHN, FRANCIS,RUPPEN, MARK, EDWARD,D

申请号：

PH12013501158

公开号：

PH12013501158B1

申请日:

2013.06.06

申请国别(地区):

PH

年份:

2015

代理人:

摘要：

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

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http://www.ckcest.cn/home/