Arthur KUNZ,Justin Keith Moran,Joseph Thomas Rubino,Neera Jain,Eugene Joseph Vidunas,John McLean Simpson,Nishith Merchant,John Francis Dijoseph,Mark Edward Ruppen,Nitin Krishnaji Damle,Paul David Robb
申请号：
US16048511
公开号：
US20180339058A1
申请日:
2018.07.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
