John McLean Simpson;Nitin Krishnaji Damle;Joseph Thomas Rubino;Mark Edward Ruppen;Arthur Kunz;Paul David Robb;Justin Keith Moran;Neera Jain;John Francis Dijoseph;Nishith Merchant;Eugene Joseph Vidunas
发明人:
Arthur Kunz,Justin Keith Moran,Joseph Thomas Rubino,Neera Jain,Eugene Joseph Vidunas,John McLean Simpson,Nishith Merchant,John Francis Dijoseph,Mark Edward Ruppen,Nitin Krishnaji Damle,Paul David Robb
申请号：
US10699874
公开号：
US08747857B2
申请日:
2003.11.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
