VLADIMIR HANES,HARTMUT BLODE,ROLF SCHUERMANN,BERND DUESTERBERG,JOACHIM MARR
申请号：
BRPI0810049
公开号：
BRPI0810049A2
申请日:
2008.04.07
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical combination product with at least 21 daily consecutive dosage units containing from 2.0 mg to 3.0 mg of drospirenone and 1.0 to 2.0 mg of 17beta-estradiol in each daily dosage unit followed by intermittent daily dosage units containing the same or smaller amount of drospirenone (i.e. 0.5 mg to 3.0 mg) as the consecutive daily dosage units wherein each intermittent daily dosage unit is preceded by at least one day without administration of drospirenone. These pharmaceutical combination products can be used for female oral contraception, guarantee a withdrawal bleeding each 4 weeks and allow for the full maintenance of the drospirenone related benefits.
