The present invention relates to a kind of combination of oral medication, it includes mixture Ibuprofen and Ibuprofen sodium dihydrate, pseudoephedrine hydrochloride and chlorpheniramine in acceptable carrier, wherein the weight ratio of brufen to Ibuprofen sodium dihydrate as free acid equivalents be 19:1 to 1:19 and total Ibuprofen greater than 15% dissolve in 15 minutes 900 milliliters 0.1 N HCl solutions pH 1.2 37 °C with 50 RPM of USP II (type) Rotatable paddles.