The present disclosure relates generally to methods and compositions for treating symptoms of Parkinsons disease and/or other movement disorders. More particularly, the present disclosure describes a method for treating symptoms of Parkinsons disease and related disorders by administering a composition comprising one or more of the following active agents estradiol, estriol, testosterone, and 19-nortestosterone. In addition, the compositions of the present invention can be used for enhancing or optimizing the effectiveness of neural stimulation in treating the symptoms of movement disorders such as Parkinsons disease.