The present invention relates to an herbal extract Solanum khasianum, Clarke. for anti-inflammatory, anthelmintic and antimicrobial activities. The ethanolic extract of Solanum khasianum, Clarke. was tested for anti-inflammatory, anthelmintic and antimicrobial activities. Anti-inflammatory activity was tested in carrageenan induced rat hind paw edema method and cotton pellet granuloma at two dose level of 200 mg/kg and 400 mg/kg respectively, Diclofenac sodium (100 mg/kg) was used as reference standard. The anti-inflammatory activity of the extract was compared with standard and control. The anthelmintic activity of the extract was tested on Tape worm, Liver fluke, Thread worm and Hook worm using two different concentrations, 100 mg/ml and 200 mg/ml. Time taken for the paralysis and death was noted and compared with the standard drug. Piperazine citrate 15 mg/ml was used as the standard. Antimicrobial activity was done by agar cup plate method at a concentration of 5 mg/ml of the extract, using fluconozole as the standard. The organisms used were Aspergillus niger and Candida albicans and the zone of inhibition was determined.