A gate valve with linkage structure includes at least a power cylinder, a valve body having a valve opening; a gate assembly in the valve body, having a main gate board and an air-tight gate board neighborly disposed, and connected with one end of the air-tight gate board by at least one parallel linkage; and at least a press bar, with one end pivotally connected to the air-tight gate board and the other end extending to form a press end. A linkage bar is pivotally connected to the press bar and also pivotally connected to the main gate board. Therefore, the gate assembly is driven to seal the valve opening; the air-tight gate board moves away from the main gate board with the linkage function; a sealing force is generated to keep the air-tightness between the air-tight gate board and the valve opening.