#$%^&*AU2005201855B220120329.pdf#####P: WPDOCS Bah NOVOGEN SPEC 1254345 AUcomple.do-03/05/05 ABSTRACT CHROMAN DERIVED COMPOUNDS & FORMULATIONS THEREOF FOR USE IN THERAPY A compound of the general formula (I): Rx R10 O (I) - -R3 0 R2 R5 y -R6 R4 wherein R 1 is hydrogen, alkyl, cycloalkyl or C(O)R 7, R2 and R3 are independently hydrogen, hydroxy, alkoxy, alkyl, cycloalkyl, halo or OC(O)R 7 , with the exception that R 2 and R 3 are not both hydrogen, R4, R5 and R6 are independently hydrogen, hydroxy, alkoxy, alkyl, cycloalkyl, acyl, NH 2, NHC1 -C4 alkyl or N(C1 -C4 alkyl)2, OC(O)R 7 or OR8 , R7 is hydrogen, alkyl, cycloalkyl, aryl, arylalkyl or amino, R8 is aryl such as phenyl or arylalkyl such as benzyl, and Rx is hydrogen hydroxy, alkoxy, alkyl, cycloalkyl or halo or a pharmaceutically acceptable salt or derivative thereof, compositions comprising same, processes for preparing said compounds and compositions. The invention also extends to use of said compounds and compositions particularly in therapy such as in the treatment of cancer.
