The disclosed invention provides a modular biofluid sensing device configured to be worn on an individual's skin. The device includes at least one primary module, at least one sensing module, and at least one specialized module. The various subsystems, components, and materials making up a biofluid sensing device are arranged for modular distribution and assembly according to a number of different organizational criteria. These criteria include distributing components into modules based on the requirements of a biofluid sensing device application, manufacturing considerations, component cost, and component lifespan.