Pharmaceutical synthesis for the treatment or delay of insulin resistance in type II diabetes mellitus, nonalcoholic fatty liver or liver, alternative pyrethroid derivatives, acetyl-CoA carboxilasa inhibitors.
BAGLEY, SCOTT WILLIAM,GRIFFITH, DAVID ANDREW,KUNG, DANIEL WEI-SHUNG.
申请号：
CL2012000999
公开号：
CL2012000999A1
申请日:
2012.04.19
申请国别(地区):
CL
年份:
2012
代理人:
摘要：
Where R1 amp； NBS is a tar (C1-C6),CYCLALQULLO (C3-C7) TETRAHYDROFURANILO OR OXETANLLO； IN WHICH SAID RENT (C1-C6.) ESTANBSP； OPTIONALLY REPLACED WITH 1 TO 2 SELECTED SUBSTITUTES INDEPENDENTLY BETWEEN ALCOXI ((L-CJ). HYDROXI, FLUacute； OR, PHENYLL, TETRAHYDROFURANYL OR OXETHANIL； R2 IS HYDROacute； GENO, COO COO, COO COO, COO COOO, COO COOO, COO COO, COO COOO R3 IS INDEPENDENTLY HYDROacute； GENO OR RENT (C1-C3)；R4 is arilo (C6-C10). Heterosexuals consisting of 5 to 12 members, 1 to 3 heterosexuals or 8 to 12 heterosexuals, and 1 to 2 heterosexuals； each heterosexual (C6-C10),5-12 heterosexuals or heterosexuals； Iacute； 8-12 heterosexuals and gays； nbs； can be replaced by 1-3 substitutes (C1-C3) independently selected from asphalt,ALCOXL (C1-C3))HALO, AMINO. RENT (C1-C3]) - AMINO, DIALQUIL (C1-C3)) - AMLNO. HYDROXL, CLANO, AMIDO, FENUO, HETEROARILO OF 5 TO 6 MEMBERS OR HETEROCICICLE OF S TO 6 MEMBERS； OR A PHARMACEUTICALLY ACCEPTABLE SALT. A PHARMACEAcute； UTICA COMPOSITION THAT CONTAINS A FOacute COMPOUND； RMULA (I). USE OF A FOacute COMPOUND； RMULA (1) AND USE OF SUCH PHARMACEUTICAL COMPOSITION； TO TREAT OR DELAY THE PROGRESSION； NOT THE START OF TYPE 2 DIABETES； HEPAAcute； INSULIN RESISTANCE <；/p>；<；p>；DONDE R1 ； ES ALQUILO ((C1-C6), CICLOALQULLO (C3-C7) TETRAHIDROFURANILO U OXETANLLO； EN EL QUE DICHO ALQUILO (C1-C6.) ESTA ； OPCIONALMENTE SUSTITUIDO CON 1 A 2 SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE ENTRE ALCOXI ((L-CJ ). HIDROXI, FLÚ；OR, FENILO, TETRAHIDROFURANILO U OXETANILO； R2 ES HIDRÓ；GENO, HALO, ALQUILO (C1-C3 ) O CIANO； CADA UNO DE R3 ES INDEPENDIENTEMENTE HIDRÓ；GENO O ALQUILO (C1-C3 )； R4 ES UN ARILO (C6-C10). HETEROARILO DE 5 A 12 MIEMBROS QUE CONTIENEN 1 A 3 HETEROATOMOS O ARILO HETEROCLCLTCO CONDENSADO DE 8 A 12 MIEMBROS QUE CONTIENEN 1 A 2 HETEROATOMOS； EN EL QUE CADA UNO DE DICHO ARILO (C6-C10), HETEROARILO DE 5 A 12 MIEMBROS O ARILO HETEROCÍ；CLICO CONDENSADO DE 8 A 12 MIEMBROS ESTA ； OPCIONALMENTE SUS
