Mark Tawa,Julius Remenar,Matthew L. Peterson,Örn Almarsson,Hector Guzman,Hongming Chen,Mark Oliveira
申请号：
US10541216
公开号：
US08362062B2
申请日:
2003.12.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
