METHOD FOR REDUCING TOXICITY OF ANTISENSE NUCLEIC ACIDS

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专利权人:

Tokyo Institute of Technology

发明人:

申请号：

EP20894697.0

公开号：

EP4067489A1

申请日:

2020.11.27

申请国别(地区):

EP

年份:

2022

代理人:

摘要：

The purpose of the present invention is to reduce the strong hepatotoxicity of antisense nucleic acids that incorporate an artificial nucleobase (e.g., LNA). The present invention provides a bridged antisense nucleic acid for which antisense nucleic acid-induced toxicity is reduced by the supplemental addition to the wing region of a specific artificial nucleobase (e.g., MCA), while retaining the sequence of the antisense nucleic acid and the number of artificial nucleobases (e.g., LNA). The present invention also provides an antisense nucleic acid drug having a remarkably-reduced hepatotoxicity.

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