ABEYWARDANE, ASITHA,BURKE, MICHAEL J.,KIRRANE, THOMAS MARTIN JR.,NETHERTON, MATTHEW RUSSELL,PADYANA, ANIL KUMAR,SMITH KEENAN, LANA LOUISE,TAKAHASHI, HIDENORI,TURNER, MICHAEL ROBERT,ZHANG, QIANG,ZHANG,
申请号：
PE0020442013
公开号：
PE09762014A1
申请日:
2012.03.13
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relating to compounds of formula (i) wherein: X is n or CH n is an integer from 0 to 3 r1 is alkyl, Halo, Oh, CN, (C1 - C6), among others R2 and R3 are independently H or alkyl (C1 - C6), R2 and R3 can join to form a Ring of 3 to 6 members comprising optionally 1 to 3 heteroatoms, OP. Additionally also substituted with 1 to 3 selected groups of Halo, Oh, (= o) C (o) oAmong others where is nr4nr5, R4 and R5 are independently H (C1 - C6), alkyl, cycloalkyl, aryl (C3 and C6) (C6 C10), among others. Preferred compounds are: N - (1 - (4 - [(3S) - 2,3 dihydro [1,4] dioxino [2,3-b] pyridin-3-yl] benzyl} il metansulfonamida piperidin-4-yl) 1 - (4 - [(2S) - 2,3 Dihydro 1,4 - benzodioxin - 2 - il] benzyl} - 2 - metilpiperidina among others. Also referred to a Pharmaceutical composition.These compounds are useful for the treatment of vascular diseases, Allergy, asthmaREFERIDO A COMPUESTOS DE FORMULA (I) DONDE: X ES N O CH n ES UN ENTERO DE 0 A 3 R1 ES HALO, OH, CN, ALQUILO (C1-C6), ENTRE OTROS R2 Y R3 SON INDEPENDIENTEMENTE H Y ALQUILO (C1-C6), R2 Y R3 PUEDEN UNIRSE PARA FORMAR UN ANILLO DE 3 A 6 MIEMBROS QUE COMPRENDE OPCIONALMENTE DE 1 A 3 HETEROATOMOS, OPCIONALMENTE TAMBIEN SUSTITUIDOS CON 1 A 3 GRUPOS SELECCIONADOS DE HALO, OH, (=O), C(O)OH, ENTRE OTROS A ES NR4NR5, DONDE R4 Y R5 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ARILO (C6-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(1-{4-[(3S)-2,3-DIHIDRO[1,4]DIOXINO[2,3-b]PIRIDIN-3-IL]BENCIL}PIPERIDIN-4-IL)METANSULFONAMIDA 1-{4[(2S)-2,3-DIHIDRO-1,4-BENZODIOXIN-2-IL]BENCIL}-2-METILPIPERIDINA ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES VASCULARES, ASMA, ALERGIA
