WANG, Zhicheng,PETRASSI, Hank Michael James,CHOI, Ha-Soon,NATALA, Srinivasa Reddy,LAJINESS, James Paul,NGUYEN, Bao
申请号：
PE0021922016
公开号：
PE14322016A1
申请日:
2015.05.12
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
The present Invention relates to a compound of formula (i) or a pharmaceutically acceptable Salt thereof where: \"-----\" links are single or double it is cr8ar8b, NR9, or r8a,R8b and R9 are H or c1-c6 alkyl R0 is H, alkyl of C1 - C6 r1 is Halo, cyano, C (OR) R11, among others R11 is H or c1-c6 alkyl R is alkyl haloalquilo C1 - C6 C1 - C6Among others, R2 and R4 are H or c1-c6 alkyl or R2 and R4 form a ciclopropilo merged with the bicyclic Ring containing R5 is H or c1-c6 alkyl or R5 and R10 form a Ring of 5 or 6 members FUSBut with the bicyclic Ring containing R6 and R7 are H or c1-c6 alkyl. It also relates to a Pharmaceutical composition.Preferred compounds are (1R, 2R, 3S, 4S) - N - (3,4-dichlorophenyl) - 3 - (2 - etilsulfonamido) pyridin-4-yl) - 7 - oxabiciclo [2.2.1] heptane-2-carboxylic carboxamide 2 - ((1R, 2S, 3R, 4S) - 3 - (3 - (4-chlorophenyl) - 1,2,4 - Oxadiazoles - 5 - il) - 7 - oxabiciclo [2.2.1] heptane-2-carboxylic carboxamido) ethyl benzoate among others.It also refers to a method of treatment. These compounds enhance or prevent the damage joints or Joint Injury in MammalsLa presente invencion se refiere a un compuesto de formula (I) o una sal farmaceuticamente aceptable del mismo donde: “-----“ son enlaces simples o dobles A es CR8aR8b, NR9, o OR8a, R8b y R9 son H o alquilo C1-C6 R0 es H, alquilo C1-C6 R1 es halo, ciano, C(O)R11, entre otros R11 es H o alquilo C1-C6 R3 es alquilo C1-C6, haloalquilo C1-C6, entre otros R2 y R4 son H o alquilo C1-C6 o R2 y R4 forman un ciclopropilo fusionado con el anillo biciclico que contiene A R5 es H o alquilo C1-C6 o R5 y R10 forman un anillo de 5 o 6 miembros fusionado con el anillo biciclico que contiene A R6 y R7 son H o alquilo C1-C6. Tambien se refiere a una composicion farmaceutica. Son compuestos preferidos: (1R,2R,3S,4S)-N-(3,4-diclorofenil)-3-(2-etilsulfonamido)piridin-4-il)-7-oxabiciclo[2.2.1]heptano-2-carboxamida 2-((1R, 2S,3R,4S)-3-(3-(4-clorofenil)-1,2,4-oxadiazol-5-il)-7-oxabiciclo[2.2.1]heptano-2-car
