LE TIRAN, ARNAUD,LE DIGUARHER, THIERRY,STARCK, JER�ME-BENO�T,HENLIN, JEAN-MICHEL,GUILLOUZIC, ANNE-FRAN�OISE,DE NANTEUIL, GUILLAUME,GENESTE, OLIVIER,DAVIDSON, JAMES EDWARD PAUL,MURRAY, JAMES BROOKE,CHE
申请号：
PE0010932014
公开号：
PE02182015A1
申请日:
2014.07.10
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Refers to phosphate Derivatives of formula (i) where X and y are each C o n A1 and A2 are together with the Atoms to which are attached a heterocycle 5 to 7 links or A1 and A2 are each h, alkyl (C1 - C6), among others t is H alkyl (C1 - C6), among others R3 is alkyl (C1 - C6), cicloalqui So, aryl, among others R4 is aryl, heteroaryl, among others R5 is H, halogen, RA, among othersRb, RC and Rd are each Halogen, alkoxy (C1 - C6), Hydroxy, trifluoromethoxy, among others.Preferred compounds are: 4 - [[3 - (6 - [(3S) - 3 - (4 - (methyl) - 3,4 - dihidroisoquinolin - 2 (1H) - yl] carbonyl} - 1,3-benzodioxol-5-yl) - - - tetrahidroindolizin 5,6,7,8] carbonyl} (1 - il phenyl) amino] phenyl phosphate disodium 4 - [[5 - (5 - Chloro - 2 - {[(3S) - 3 - (4 - (methyl) - 3,4 - dihidroisoquinolin - 2 (1H) - yl] Carboni L phenyl) - 1},2 - dimethyl - 1H pyrrole carbonyl} il] - 3 - (pyridin-4-yl) amino] phenyl phosphate disodium among others. It also relates to a Pharmaceutical composition. These compounds are useful in the treatment of cancer, autoimmune diseasesSE REFIERE A DERIVADOS DE FOSFATOS DE FORMULA (I) DONDE X E Y SON CADA UNO C O N A1 Y A2 FORMAN JUNTO CON LOS ATOMOS A LOS QUE ESTAN UNIDOS UN HETEROCICLO DE 5 A 7 ESLABONES O A1 Y A2 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS T ES H, ALQUILO(C1-C6), ENTRE OTROS R3 ES ALQUILO(C1-C6), CICLOALQUILO, ARILO, ENTRE OTROS R4 ES ARILO, HETEROARILO, ENTRE OTROS R5 ES H, HALOGENO, ENTRE OTROS Ra, Rb, Rc Y Rd SON CADA UNO HALOGENO, ALCOXI(C1-C6), HIDROXI, TRIFLUOROMETOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[{[3-(6-{[(3S)-3-(MORFOLIN-4-ILMETIL)-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]CARBONIL}-1,3-BENZODIOXOL-5-IL)-5,6,7,8-TETRAHIDROINDOLIZIN-1-IL]CARBONIL}(FENIL)AMINO]FENIL FOSFATO DE DISODIO 4-[{[5-(5-CLORO-2-{[(3S)-3-(MORFOLIN-4-ILMETIL)-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]CARBONIL}FENIL)-1,2-DIMETIL-1H-PIRROL-3-IL]CARBONIL}(PIRIDIN-4-IL)AMINO]FENIL FOSFATO DE DISODIO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS
