REN, PINGDA,LIU, YI,LI, LIANSHENG,CHAN, KATRINA,WILSON, TROY EDWARD,CAMPBELL, SIMON FRASER
申请号：
PE0002292012
公开号：
PE11482012A1
申请日:
2010.08.17
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula I, where X is o, S, N W1 is n, c = o, NH, among others W2 is CH2 = C, N, o, among others w3 is n, NH, N - (alkyl of C1 - C6), among others W4 is n c = o, CR6, among others where no more than two n Atoms and Two C = o groups are adjacent W5 n, CR7 W6 is n, CR8 R1 and R2 are each h, alkyl, cycloalkyl, heteroalquilo alquenilo heteroaryl,,,Among others, R6, R7 and R8 are each heteroalquilo h, alkyl, cycloalkyl, aryl, alquenilo, arylalkyl, alkoxy, among others. Preferred compounds are: 5 - (3 - (pyridin-4-yl) imidazo [1,2-a] pyridin-3 (IL - 6) benzo [d] oxazole - 2 - Amine 2 - (4 - (4 - (2 - aminobenzo [d] oxazole - 5 - methyl - 3 - il) 2 - oxo 2,3 dihydro - 1H imidazo [4,5-c] quinolin-1 - 1 - il) phenyl) - 2-methylpropanenitrile among others.These compounds are inhibitors of phosphatidyl inositol 3 Kinase (PI3 kinase) useful in the treatment of emphysema, Asthma, psoriasis, Allergy, anaphylaxis, restenosis, diabetes, among othersREFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES O, S, N W1 ES N, C=O, NH, ENTRE OTROS W2 ES N, CH2, C=O, ENTRE OTROS W3 ES N, NH, N-(ALQUILO C1-C6), ENTRE OTROS W4 ES N, C=O, CR6, ENTRE OTROS EN DONDE NO MAS DE DOS ATOMOS DE N Y NO MAS DE DOS GRUPOS C=O SON ADYACENTES W5 ES N, CR7 W6 ES N, CR8 R1 Y R2 SON CADA UNO H, ALQUILO, HETEROALQUILO, ALQUENILO, CICLOALQUILO, HETEROARILO, ENTRE OTROS R6, R7 Y R8 SON CADA UNO H, ALQUILO, HETEROALQUILO, ALQUENILO, CICLOALQUILO, ARILO, ARILALQUILO, ALCOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-(3-(PIRIDIN-4-IL)IMIDAZO[1,2-a]PIRIDIN-6-IL)BENZO[d]OXAZOL-2-AMINA 2-(4-(8-(2-AMINOBENZO[d]OXAZOL-5-IL)-3-METIL-2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-c]QUINOLIN-1-IL)FENIL)-2-METILPROPANONITRILO ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFATIDIL INOSITOL-3 QUINASA (PI3 QUINASA) UTILES EN EL TRATAMIENTO DE ASMA, ENFISEMA, PSORIASIS, ALERGIA, ANAFILAXIS, REESTENOSIS, DIABETES, ENTRE OTROS
