STENKAMP, DIRK,MULLER, STEPHAN GEORG,ROTH, GERALD JURGEN,LUSTENBERGER, PHILIPP,RUDOLF, KLAUS,LEHMANN-LINTZ, THORSTEN,ARNDT, KIRSTEN,LOTZ, RALF R. H.,LENTER, MARTIN,WIELAND, HEIKE-ANDREA
申请号：
CA2504207
公开号：
CA2504207C
申请日:
2003.10.28
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to amide compounds of general formula I(See Formula I)wherein A, B and Y are carbo- or heterocyclic groups； b is 0 or 1； X is analkylenebridge； W is alkylene, alkenylene, alkyloxy, alkylamino, etc.； Z is a bond oralkyienebridge； R1, R2 and R3 are hydrogen, alkyl, cycloalkyl, etc., or R1 and R2 formanalkylene bridge. Moreover the invention relates to pharmaceutical compositionscontaining at least one amide according to the invention. In view of the MCHreceptor-antagonistic activity the pharmaceutical compositions according totheinvention are suitable for the treatment of metabolic disorders and/or eatingdisorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
