Philipp Lustenberger;Ralf R. H. Lotz;Dirk Stenkamp;Martin Lenter;Thorsten Lehmann-Lintz;Kristen Arndt;Klaus Rudolf;Gerald Juergen Roth;Stephan Georg Mueller
发明人:
Dirk Stenkamp,Stephan Georg Mueller,Gerald Juergen Roth,Thorsten Lehmann-Lintz,Klaus Rudolf,Philipp Lustenberger,Kristen Arndt,Ralf R. H. Lotz,Martin Lenter
申请号：
US12121251
公开号：
US08618132B2
申请日:
2008.05.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to alkyne compounds of general formula Iwherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
