< Topic >The production method of the organism wounding cladding material of this invention, it is gas permeability, but vis-a-vis the bacterium although it is impermeability, you use, being convenient, that production method is simple, there are times which possess satisfactory organism compatibility, possess durable flexibiility.SolutionsThe organism wounding cladding material, it possesses the substrate (1) step and the said substrate which offer the natural animal organization which step and the said substrate which it builds a bridge and locks (1) and (1) step and the said substrate which minimize the antigen of origin in (1) active layer the step which (2) is installed and, is produced with the method of including.< Selective figure >Figure 1【課題】本発明の生体創傷被覆材の作製方法は、ガス透過性ではあるが細菌に対しては不透過性であり、使用するのに便利でその作製方法が簡単な、良好な生体適合性を有し、耐久的な可撓性を有することにある。【解決手段】生体創傷被覆材は、基質(1)を有する天然の動物組織を提供するステップと、該基質(1)を架橋かつ固定するステップと、該基質(1)由来の抗原を最小化するステップと、該基質(1)に活性層(2)を組み込むステップと、を含む方法で作製される。【選択図】図1