A method and system for correcting power line interferences in an ElectroCardioGram (ECG) signal is disclosed. The method comprises: providing an input signal having ECG signal along with interference signals to a digital filter capable of filtering at a preset frequency and identifying current power line frequency, if any, from the filtered input signal. The method further includes providing a look up table with index number for a set of frequency levels and corresponding filter coefficients, the set of frequency includes incremental steps in the range of possible variations on the power line frequency. The filter coefficient corresponding to current power line frequency is identified from the look up table. The digital filter is configured using the identified filter coefficient and the input signal is filtered using the re-configured digital filter.
