The present invention discloses compounds according to Formula I:Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (S1P) receptor, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering the compound of the invention.本發明揭示如式I之化合物：其中R1、R2、L、A1、A2、A3、Cy及下標n如本文所定義。 本發明係關於神經鞘胺醇1-磷酸酯(sphingosine 1-phosphate；S1P)受體之拮抗劑化合物、用於其等生產之方法、包含其等之醫藥組合物及使用其等之治療方法，藉由投與本發明之化合物來預防及/或治療包括纖維化疾病、發炎性疾病、呼吸道疾病、自體免疫疾病、代謝疾病、心血管病及/或增生性疾病之疾病。
