作為RORγT調節劑之6-胺基吡啶-3-基噻唑农业专利-农业学术服务平台

发明人:: GOLDBERG, STEVEN,戈德堡　史蒂芬,MCCLURE, KELLY,麦克鲁尔　凯利,麥克魯爾　凱利,TANIS, VIRGINIA M.,塔尼斯　维吉尼亚,塔尼斯　維吉尼亞,FENNEMA, ELIZABETH G.,芬内马　伊丽莎白,芬內馬　伊麗莎白,LEBSACK, ALEC D.,莱布塞克　亚力克,萊布塞克　亞力克,MARTIN, CONNOR L.,马丁　康纳,戈德堡史蒂芬,麦克鲁尔凯利,麥克魯爾凱利,塔尼斯维吉尼亚,塔尼斯維吉尼亞,芬内马伊丽莎白,芬內馬伊麗莎白,莱布塞克亚力克,萊布塞克亞力克,马丁康纳

摘要：: The present invention comprises compounds of Formula I. wherein: A1, A2, A3, A4, A5, R1, and R2 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.本發明包含式I之化合物其中A1、A2、A3、A4、R5、R1、及R2係定義於說明書中。本發明亦包含一種治療或改善症候群、病症或疾病的方法，其中該症候群、病症或疾病係類風濕性關節炎或乾癬。本發明亦包含一種藉由投予治療有效量之至少一種式I之化合物來調節哺乳動物中之RORγt活性的方法。