A compound that is according to Formula I: ** Formula ** or is a pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein: Y1 is O or S； Z1 is CH or N； A is phenyl or a 6-membered heteroaryl； R1 is H； each of R2 and R3 is, independently of each other, H, (C1-C6) alkyl optionally substituted with one or more of the same or different R11 groups, (C3-C8) cycloalkyl optionally substituted with one or more of the R11 groups same or different, cycloalkylalkyl (C4-C11) optionally substituted with one or more of the same or different R11 groups, aryl (C5-C10) optionally substituted with one or more of the same or different R11 groups, arylalkyl (C6-C16) optionally substituted with one or more of the same or different R11 groups, 2-6 membered heteroalkyl optionally substituted with one or more of the same or different R11 groups, 3-8 cycloheteroalkyl, optionally substituted with one or more of the groups Same or different R11, 4-11 membered cycloheteroalkylalkyl, optionally substituted with one or more of the same or different R11 groups, 5-10 membered heteroaryl optionally substituted with one or more of the same R11 groups s or different, or 6-16 membered heteroarylalkyl optionally substituted with one or more of the same or different R11 groups； each of R4 and R5 is, independently of each other, H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halogen, halo (C1-C6) haloalkoxy (C1-C6) alkyl or hydroxyalkyl (C1-C6)； or, alternatively, R4 and R5, taken together with the carbon atom to which they are attached, form a spirocycloalkyl or a spirocycloheteroalkyl, or, alternatively, R4 and R5, taken together with the carbon atom to which they are attached, form a group C>； = O； each of R6 and R7 is, independently of each other, H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C1-C6) alkoxy, halogen, halo (C1-C6) haloalkoxy (C1-C6) alkyl or hydroxyalkyl (C1-C6)； or, alternatively, R6 and R7, taken together with the carbon atom to which they are attached, form a spirocyc
