The present invention features processes of making tablets having reduced internal fractures. In one aspect, the processes comprise the steps of (1) compressing a pre-tabletting material in a die to form a tablet, where an internal surface of the die is lubricated with at least one lubricant, and the pre-tabletting material comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer； and (2) ejecting said tablet from said die. In another aspect, the processes employ a granular or powdery pre-tabletting material which comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer, wherein 90% of the particles in the pre-tabletting material are smaller than 400 μm.本發明特徵在於一種製備內部破裂減少之錠劑之方法。在一個態樣中，該等方法包括以下步驟：(1)在模具中壓縮預製錠材料以形成錠劑，其中模具內表面用至少一種潤滑劑潤滑，且預製錠材料包括至少一種治療藥劑及至少一種醫藥上可接受之聚合物；及(2)自該模具脫出該錠劑。在另一態樣中，該等方法使用顆粒狀或粉末狀預製錠材料，其包括至少一種治療藥劑及至少一種醫藥上可接受之聚合物，其中預製錠材料中90%的粒子小於400微米。
