Nishanth Gopinathan,Rudolf Schroeder,Albert Santiago,Lynn V. Faitsch,Jacqueline Wardrop,John B. Morris,Martin Bultmann,Heinz Schlayer
申请号：
US13835436
公开号：
US20130203791A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention features processes of making tablets having reduced internal fractures. In one aspect, the processes comprise the steps of (1) compressing a pre-tabletting material in a die to form a tablet, where an internal surface of the die is lubricated with at least one lubricant, and the pre-tabletting material comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer； and (2) ejecting said tablet from said die. In another aspect, the processes employ a granular or powdery pre-tabletting material which comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer, wherein 90% of the particles in the pre-tabletting material are smaller than 400 μm.
