Disclosed is a compound, comprising a single-stranded modified oligonucleotide consisting of 10 to 30 linked nucleosides and having a nucleobase sequence comprising at least 8 contiguous nucleobases of any of the nucleobase sequences disclosed, wherein at least one nucleoside of the single-stranded modified oligonucleotide comprises a modified sugar and the single-stranded modified oligonucleotide is at least 90% complementary to SEQ ID NO: 1, wherein the sequences are as defined in the specification. Also disclosed is the use of the compound for treating a HBV-related disease, disorder or condition