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Modulation of hepatitis b virus (hbv) expression
专利权人:
ISIS PHARMACEUTICALS INC.
发明人:
MCCALEB MICHAEL L.,SWAYZE ERIC E.,FREIER SUSAN M.
申请号:
NZ61651212
公开号:
NZ616512A
申请日:
2012.04.20
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Disclosed is a compound, comprising a single-stranded modified oligonucleotide consisting of 10 to 30 linked nucleosides and having a nucleobase sequence comprising at least 8 contiguous nucleobases of any of the nucleobase sequences disclosed, wherein at least one nucleoside of the single-stranded modified oligonucleotide comprises a modified sugar and the single-stranded modified oligonucleotide is at least 90% complementary to SEQ ID NO: 1, wherein the sequences are as defined in the specification. Also disclosed is the use of the compound for treating a HBV-related disease, disorder or condition
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