Alexander Berthold Hendrik Bakker,Pieter Fokko Van Loo
申请号：
US15205629
公开号：
US09914777B2
申请日:
2016.07.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention is among others concerned with human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a variable region that comprises the amino acid sequence (SEQ ID NO: 61):QVQLV QSGGG VVQPG RSLRL SCVAS GFTFS SYGMH WVRQA PGKGL EWVAA IWYX1X2 RKQDY ADSVK GRFTI SRDNS KNTLY LQMNS LRAED TAVYY CTRGT GYNWF DPWGQ GTLVT VSS with 0-5 amino acid insertions, deletions, substitutions, additions or a combination thereof at one or more positions other than the position indicated by X1X2 wherein X1=N and X2=A X1=N and X2=T X1=S and X2=G X1=H and X2=G X1=D and X2=G or X1=H and X2=A. The invention is also concerned with bispecific antibodies that have a heavy chain as defined herein above. The invention is also concerned with methods of production of the antibody, cells producing the antibody and with (medical) uses of the antibody.
