BAKKER ALEXANDER BERTHOLD HENDRIK,VAN LOO PIETER FOKKO
申请号：
IN201847001277
公开号：
IN201847001277A
申请日:
2018.01.11
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The disclosure relates to human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a variable region that comprises the amino acid sequence: QVQLV QSGGG VVQPG RSLRL SCVAS GFTFS SYGMH WVRQA PGKGL EWVAA IWYX1X2RKQDY ADSVK GRFTI SRDNS KNTLY LQMNS LRAED TAVYY CTRGT GYNWF DPWGQ GTLVT VSS with 0 5 amino acid insertions deletions substitutions additions or a combination thereof The disclosure also relates to with bispecific antibodies that have a heavy chain as defined herein above. Methods of production of the antibody cells producing the antibody and with (medical) uses of the antibody are provided.
