Bakker, Alexander Berthold Hendrik,Bakker, Alexander Berthold Hendrik,Van Loo, Pieter Fokko,Van Loo, Pieter Fokko
申请号：
HRP20181802
公开号：
HRP20181802T1
申请日:
2018.10.30
申请国别(地区):
HR
年份:
2018
代理人:
摘要：
The present disclosure relates to human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a variable region that comprises the amino acid sequence: QVQLV QSGGG VVQPG RSLRL SCVAS GFTFS SYGMH WVRQA PGKGL EWVAA IWYX 1 X 2 RKQDY ADSVK GRFTI SRDNS KNTLY LQMNS LRAED TAVYY CTRGT GYNWF DPWGQ GTLVT VSS with 0-5 amino acid insertions, deletions, substitutions, additions or a combination thereof , The disclosure also relates to bispecific antibodies that have a heavy chain as defined herein above. Methods of production of the antibody, cells producing the antibody and with (medical) uses of the antibody are provided.
