WANG, DONG,KOPECEK, JINDRICH,MILLER, SCOTT C.,KOPECKOVA, PAVLA
申请号：
CA2557448
公开号：
CA2557448C
申请日:
2005.03.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
This invention relates to biotechnology, more particularly, to water-solublepolymeric delivery systems for the imaging, evaluation and/or treatment ofrheumatoid arthritis and other inflammatory diseases. Using modern MR imagingtechniques, the specific accumulation of macromolecules in arthritic joints inadjuvant-induced arthritis in rats is demonstrated. The strong correlationbetween the uptake and retention of the MR contrast agent labeled polymer withhistopathological features of inflammation and local tissue damagedemonstrates the practical applications of the macromolecular delivery systemof the invention.
