Wilhelmus G.J. HOL,Eric T. LARSON,Dustin James MALY,Wesley C. VAN VOORHIS,Ethan MERRITT,Kayode K. OJO
申请号：
US16402227
公开号：
US20190358231A1
申请日:
2019.05.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.
