ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON TOXOPLASMOSE, KRYPTOSPORIDIOSE UND ANDEREN MIT SPOROZOEN ASSOZIIERTEN ERKRANKUNGEN

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专利权人:

University of Washington

发明人:

HOL, Wilhelmus G.j.,LARSON, Eric T.,MALY, Dustin James,VAN VOORHIS, Wesley C.,MERRITT, Ethan,OJO, Kayode K.

申请号：

EP16743998

公开号：

EP3250290A4

申请日:

2016.01.26

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.

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