UNIVERSITE LIBRE DE BRUXELLES;SOUBHYE, JALAL;DUFRASNE, FRANCOIS;VAN ANTWERPEN, PIERRE
发明人:
申请号：
IL21639811
公开号：
IL216398D0
申请日:
2011.11.16
申请国别(地区):
IL
年份:
2012
代理人:
摘要：
The invention relates to a compound of formula (Ia) wherein n is an integer between 2 and 10, R1 and R2 independently represent a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl and aminoalkyl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form a four to ten-membered heterocycle, R5 represents independently in each of the n units a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, halogen, alkoxy, aminoalkyl and alkylamino； or a pharmaceutically acceptable salt thereof, with the proviso that the 5-fluorotryptamine is excluded, for the treatment or the prophylaxis of neuroinflammatory diseases or disorders. The invention also relates to a pharmaceutical composition, a method for inhibiting myeloperoxidase enzyme activity, to a method for inhibiting Low density lipoproteins oxidation.
