BROWN MATTHEW FRANK,DERMENCI ALPAY,FENSOME ANDREW,GERSTENBERGER BRIAN STEPHEN,HAYWARD MATTHEW MERRILL,WRIGHT STEPHEN WAYNE,YANG XIAOJING,XING LI HUANG,OWEN DAFYDD RHYS
申请号：
SV2018005726
公开号：
SV2018005726A
申请日:
2018.07.18
申请国别(地区):
SV
年份:
2018
代理人:
摘要：
A compound has the following structure: (see formula) or a pharmacologically acceptable salt, or a pharmacologically acceptable compound or a pharmacologically acceptable solution of salt, where A, A'and A'are independent. Or, C = o, c-r'o n-r,,Among them, R'and R'may be independent H, amino, NR7Cor6, Cor6, CONR7R8, C1-C6 asphalt or hydroxyl (C1-C6 asphalt).R "may or may not exist, and exists where the Valencia Rules permit, and does not exceed A, A'and A" is O, C = O； R0 and R are independent H, BR, CL, F or C1-C6 tars； R1 is H, C1-C6 tars or hydroxyl (C1-C6 tars)；R2 was selected from a group consisting of H, C1-C6 tar, C1-C6 alcox and hydroxyl group (C1-C6 tar).Phenyl (C1-C6 tar)Thyroid, Heterosexual, Heterosexual, Cor6, OCOR6. - COUR6, NR7COR6, CONR7R8 Y-(CH2) N-W, where W is cyanide, hydroxi, C3-C8 cycloquilo, SO2NR8 and SO2-R9, where R9 is C1-C6 tar, C3-C8 cycloquilo, heteromorphic or heteromorphic； in this case, no asphalt, cyclopropyl compound, heteromorphic or heteromorphic compound can be replaced or replaced. O-halogen, cyanide, hydrogen XI or C1-C6 tar； X is C-R3 or N, where R3 can be H or C1-C6 tar； R4 and R5 are independent H, ammonia, C1-C6 tar or hydroXI (C1-C6 tar)；R6, R7 and R8 are H, C1-C6 tar, C1-C4 Alcoy (C1-C6 tar) or C3-C8 cycloquilo, i.e. C1-C6 C6 tar can be replaced by halogenation, CN or hydroxyl groups； or R7 and R8 are attached to form rings of 5 or 6 members in which the ring substance is replaced. Optional halides, hydroxyl groups, CN or C1-C6 tars； and N are 0, 1, 2 or 3. Therapeutic methods, such as quinas Yanu inhibitors and pharmaceutical ingredients containing inventive compounds, and combinations of these compounds with other therapeutic agents are also provided.UN COMPUESTO QUE TIENE LA SIGUIENTE ESTRUCTURA: (VER FORMULA) O UNA SAL DE ESTE ACEPTABLE DESDE EL PUNTO DE VISTA FARMACÉUTICO, O UN SOLVATO ACEPTABLE DESDE EL PUNTO DE VISTA FARMACÉUTICO DE UN COMPUESTO O UNA SAL ACEPTABLE DESDE EL PUNTO DE VISTA FARMACÉUTICO, EN DONDE A,
