BROWN, MATTHEW FRANK,HAYWARD, MATTHEW MERRILL,WRIGHT, Stephen Wayne,FENSOME, Andrew,DERMENCI, Alpay,GERSTENBERGER, Brian Stephen,OWEN, Dafydd Rhys,XING, Li Huang,YANG, Xiaojing
申请号：
CO2018008799
公开号：
CO2018008799A2
申请日:
2017.02.10
申请国别(地区):
CO
年份:
2018
代理人:
摘要：
A compound having the following Structure: (i) or a Salt of the pharmaceutical acceptable from the point of view,Or a solvate acceptable from the point of view of a Pharmaceutical Compound or Salt acceptable from the point of view of Pharmaceuticals, where, 'and' Or 'are independently, c = o, C - N - R' Or 'r',Where R 'and R' 'can be independently - H, amino, nr7cor6, cor6, - conr7r8, C1 - C6 (C1 - C6 Hydroxy alkyl or alkyl), and R' can be present or absent.And this is where the rules of Valencia allows, and where no more than one of a, a 'and' Or 'or C = o； R and R0 are independently h, BR, CL, F, or c1-c6 alkyl； r1 is H,C1 - C6 (C1 - C6 Hydroxy alkyl or alkyl； R2 is selected from the group consisting of H, C1 - C6 C1 - C6 alkyl, alkoxy, Hydroxy (C1 - C6 alkyl, phenyl (C1 - C6 alkyl), Formilo, Heterocyclic and heteroaryl,- cor6 ocor6 coor6, -, -, - and - nr7cor6, conr7r8 - (CH2) n - W, where W is Ciano, cycloalkyl Hydroxy C3, C8 so2nr7r8 -, - and - SO2 - R9, where R0 is C1 - C6 C3 - C8 alkyl, cycloalkyl,Heterocyclic and heteroaryl； where each alkyl, cycloalkyl or Heterocyclic and heteroaryl can be replaced or not replaced by Halo, cyano, Hydroxy or c1-c6 alkyl； X is C - or N R3,Where R3 may be H or c1-c6 alkyl； R4 and R5 are independently H or c1-c6 alkyl amino, Hydroxy (C1 - C6 alkyl), R6, R7 and R8 are each independently, h, c1-c6 alkylC1 - C4 (c1-c6 alkoxy alkyl or cycloalkyl) C3, C8, C6 C1 alkyl optionally replaced with a Halo, or cn or Hydroxy； R7 and R8, together with the Atom attached to these.Form a Ring of 5 or 6 members, where the ring is optionally replaced with Halo, Hydroxy, cn or c1-c6 alkyl； n is 0, 1, 2 or 3.Also provided are methods of treatment such as Janus Kinase Inhibitors and Pharmaceutical compositions containing the compounds of the Invention and combinations of these with othersTherapeutic people.Un compuesto que tiene la siguiente estructura: (I) o una sal de este aceptable desde el punto de vista farmacéutico, o un solvato aceptable desde
