BROWN, Matthew Frank,DERMENCI, Alpay,FENSOME, Andrew,GERSTENBERGER, Brian Stephen,HAYWARD, Matthew Merrill,OWEN, Dafydd Rhys,WRIGHT, Stephen Wayne,XING, Li Huang,YANG, Xiaojing,BROWN MATTHEW FRANK,DERMENCI ALPAY,FENSOME ANDREW,GERSTENBERGER BRIAN STEPHEN,HAYWARD MATTHEW
申请号：
CL2018002358
公开号：
CL2018002358A1
申请日:
2018.08.17
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
A compound having the following structure, or a Salt of the pharmaceutical acceptable from the point of view,Or a solvate acceptable from the point of view of a Pharmaceutical Compound or Salt acceptable from the point of view of product, where, 'and' Or 'are independently, c = o, C - N - R' Or 'r',Where R 'and R' 'can be independently - H, amino, nr7cor6, cor6, - conr7r8, C1 - C6 (C1 - C6 Hydroxy alkyl or alkyl), and R' can be present or absent.And this is where the rules of Valencia allows, and where no more than one of a, a 'and' Or 'or C = o； R and R0 are independently h, BR, CL, F, or c1-c6 alkyl； r1 is H,C1 - C6 (C1 - C6 Hydroxy alkyl or alkyl； R2 is selected from the group consisting of H, C1 - C6 C1 - C6 alkyl, alkoxy, Hydroxy (C1 - C6 alkyl, phenyl (C1 - C6 alkyl), Formilo heteroaryl heterocÍclico,,,- cor6 ocor6 coor6, -, -, - and - nr7cor6, conr7r8 - (CH2) n - W, where W is Ciano, cycloalkyl Hydroxy C3, C8 so2nr7r8 -, - and - SO2 - R9, where R0 is C1 - C6 C3 - C8 alkyl, cycloalkyl,Heteroaryl or heterocÍclico； where each heterocÍclico heteroaryl alkyl, cycloalkyl, or can be replaced or not replaced by Halo, cyano, Hydroxy or c1-c6 alkyl； X is C - or N R3,Where R3 may be H or c1-c6 alkyl； R4 and R5 are independently H or c1-c6 alkyl amino, Hydroxy (C1 - C6 alkyl), R6, R7 and R8 are each independently, h, c1-c6 alkylC1 - C4 (c1-c6 alkoxy alkyl or cycloalkyl) C3, C8, C6 C1 alkyl optionally replaced with a Halo, or cn or Hydroxy； R7 and R8, together with the Atom attached to these.Form a Ring of 5 or 6 members, where the ring is optionally replaced with Halo, Hydroxy, cn or c1-c6 alkyl； n is 0, 1, 2 or 3.Also provided are methods of treatment such as Janus Kinase Inhibitors and Pharmaceutical compositions containing the compounds of the Invention and combinations of these with othersPeople Therapy.<；p>；UN COMPUESTO QUE TIENE LA SIGUIENTE ESTRUCTURA, O UNA SAL DE ESTE ACEPTABLE DESDE EL PUNTO DE VISTA FARMACÉ；UTICO, O UN SOLVATO ACEPTABLE DESDE EL PUNT
